Kaposi sarcoma in a guereza monkey
Photo by Bryan Hanson on Unsplash
What is it about?
The Kaposi Sarcoma Herpesvirus (KSHV) causes Kaposi Sarcoma (KS) and other cancers in humans. In Europe, KS patients are usually coinfected with HIV and an immunosuppressive virus, human immunodeficiency virus (HIV). In contrast, the majority of KS patients in Africa is not coinfected with HIV, suggesting that genetic factors play a role in disease development in this patient group. KSHV-related viruses have also been discovered in diverse non-human primates but infected animals only develop disease upon immunosuppression. This manuscript describes the identification of a new KSHV-related virus in NHPs. The new virus, termed Colobine Gammaherpesvirus 1 (CbGHV-1), was detected in a mantled guereza with KS-like disease. The virus was present in cancerous tissue and the animal was not coinfected by an immunosuppressive virus. This suggests that infection of guererza monkeys with CbGHV-1 might be sufficient to cause KS.
Why is it important?
We report the identification of a new virus provide evidence that NHP infection by this virus might be sufficient to cause KS - a finding that has not been made for other KSHV-related viruses/other NHP.
The following have contributed to this page: Professor Stefan Pöhlmann