Kaposi Sarcoma in Mantled Guereza

Anna Grewer, Martina Bleyer, Kerstin Mätz-Rensing, Alexander S. Hahn, Tim Rüggeberg, Gregor Babaryka, Andre Zimmermann, Stefan Pöhlmann, Artur Kaul
  • Emerging Infectious Diseases, August 2019, Centers for Disease Control and Prevention (CDC)
  • DOI: 10.3201/eid2508.181804

Kaposi sarcoma in a guereza monkey

Photo by Bryan Hanson on Unsplash

Photo by Bryan Hanson on Unsplash

What is it about?

The Kaposi Sarcoma Herpesvirus (KSHV) causes Kaposi Sarcoma (KS) and other cancers in humans. In Europe, KS patients are usually coinfected with HIV and an immunosuppressive virus, human immunodeficiency virus (HIV). In contrast, the majority of KS patients in Africa is not coinfected with HIV, suggesting that genetic factors play a role in disease development in this patient group. KSHV-related viruses have also been discovered in diverse non-human primates but infected animals only develop disease upon immunosuppression. This manuscript describes the identification of a new KSHV-related virus in NHPs. The new virus, termed Colobine Gammaherpesvirus 1 (CbGHV-1), was detected in a mantled guereza with KS-like disease. The virus was present in cancerous tissue and the animal was not coinfected by an immunosuppressive virus. This suggests that infection of guererza monkeys with CbGHV-1 might be sufficient to cause KS.

Why is it important?

We report the identification of a new virus provide evidence that NHP infection by this virus might be sufficient to cause KS - a finding that has not been made for other KSHV-related viruses/other NHP.

Perspectives

Professor Stefan Pöhlmann
German Primate Center

Experimental infection of guereza mith CbGHV-1 might allow establishment of a new animal model for KSHV infection of humans.

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http://dx.doi.org/10.3201/eid2508.181804

The following have contributed to this page: Professor Stefan Pöhlmann