Impact of diabetes on corneal thickness and intra ocular pressure

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abetic people have two times increased chance of develop -ing glaucoma compared with non-diabetics. 2 Several studieshad proved that diabetes is a risk factor for glaucoma.3 The el-evated blood glucose level in diabetes may induce an osmoticgradient and attract fluid into the intraocular space resultingin elevated IOP. Diabetic individuals had been proved to havethicker corneas and increased central corneal thickness hadbeen proved to be associated with the onset and progressionof glaucoma. 4,5 Hence this study was conducted to evaluate.ABSTRACTIntroduction: Diabetic patients had been proved to have thicker corneas and are commonly associated with primary open-angleglaucoma. Diabetic people have two times increased chance of developing glaucoma compared with non-diabeticsAim: To study the association of central corneal thickness and the intraocular pressure in type 2 diabetic patients and to comparethe same with the healthy control subjects.Materials and Methods: This case-control study was conducted with fifty proven type 2 diabetic patients and healthy control.Study participants underwent slit lamp examination, fundus examination, IOP measurement with Applanation tonometer andcorneal thickness with OCT. The screening laboratory tests included fasting and postprandial blood sugar and also glycatedhaemoglobin (HbA1C) levels.Results: Mean age of the patients was 55 in the diabetes group and 57 in the control group. Males were more in the diabeticgroup and an equal number in the control group. Mean IOP in the control group was 13.76 ± 1.74 and in the test group was 19.29± 2.38. Increase in HbA1C level showed a significant increase in intraocular pressure. Diabetic patients showed a significantincrease in corneal thickness. Statistically, a significant difference was observed in the Mean comparison of all variables likeHbA1C, corneal thickness and IOP between the diabetic and control group.Conclusion: Adult-onset Diabetes has been proved to be a modifiable risk factor for open-angle glaucoma, and periodic screen-ing will help in the early diagnosis of glaucoma and avoid blindness.Key Words: Type 2 Diabetes Mellitus, Corneal Thickness, Intra Ocular Pressure, Healthy ControlAssociation of Type 2 Diabetes Mellitus withCentral Corneal Thickness and IntraocularPressure – A Case Control StudyK. Kalaivani1, P. Mishra2, S. Sathish Kumar31PhD Scholar in Ophthalmology, Rajah Muthiah Medical College, Annamalai University, India; 2Professor of Ophthalmology, RajahMuthiah Medical College, Annamalai University, India; 3Assistant Professor in Community Medicine, Vinayaka Mission’s Medical College,Vinayaka Mission’s Research Foundation (DU), India.IJCRRSection: HealthcareSci. Journal ImpactFactor: 6.1 (2018)ICV: 90.90 (2018)Copyright@IJCRR Page 2 Int J Cur Res Rev | Vol 12 • Issue 22 • November 2020Kalaivani et al.: Association of type 2 diabetes mellitus with central corneal thickness and intraocular pressure – a case control study49the association between adult-onset diabetes, central cornealthickness and Intraocular pressure.MATERIALS AND METHOD (PDF) Association of Type 2 Diabetes Mellitus with Central Corneal Thickness and Intraocular Pressure – A Case Control Study. Available from: https://www.researchgate.net/publication/347131672_Association_of_Type_2_Diabetes_Mellitus_with_Central_Corneal_Thickness_and_Intraocular_Pressure_-_A_Case_Control_Study#fullTextFileContent [accessed Mar 03 2025].

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