What is it about?
L-NAME-treated animals exhibited decreased anxiety-like behavior in the light/dark box and open field tests, with no change in locomotor activity. Additionally, they demonstrated decreased depression-like behavior in the forced swim test and no change in pain perception in the tail-flick test.
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Why is it important?
The nitrergic system is possibly involved in neural circuitry development that regulates behaviors since blocking perinatal nitric oxide production decreases anxiety- and depression-like behaviors in adult mice
Perspectives
the nitrergic system is a potential target for studying trait anxiety progression. Although nitric oxide participates in adult pain perception, the nitrergic system may not be involved in the nociception circuitry.
Full Professor Ahmed R. G.
Division of Anatomy and Embryology, Zoology department, Faculty of Science, Beni-Suef University, Egypt.
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This page is a summary of: Perinatal N(G)-Nitro-L-arginine methyl ester administration decreases anxiety- and depression-like behaviors in adult mice, Einstein (São Paulo), January 2023, Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein,
DOI: 10.31744/einstein_journal/2023ao0302.
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