What is it about?
Histone modification can effect on the prognosis of the glioblastoma patients by controlling the expression of MGMT gene.
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Why is it important?
The methylation of MGMT promoter is the most important genetic marker for the predicting the response for the standarad treatment including concurrent chemoradiotherapy using temozolomide for the glioblastomas. The ability of controlling the expression of MGMT epigenetically can improve the response for the standard treatment of glioblastomas.
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This page is a summary of: Increased expression of the histone H3 lysine 4 methyltransferase MLL4 and the histone H3 lysine 27 demethylase UTX prolonging the overall survival of patients with glioblastoma and a methylated MGMT promoter, Journal of Neurosurgery, May 2017, Journal of Neurosurgery Publishing Group (JNSPG),
DOI: 10.3171/2016.4.jns1652.
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