What is it about?
The Mammalian Target of Rapamycin (mTOR) signaling pathway is activated by the small G-protein Ras Homolog Enriched in Brain (Rheb), which is encoded by the Rheb1 and Rheb-like-1 (RhebL1) genes. Here we investigated the role of RhebL1 during human influenza A/NWS/33 (NWS/33) (H1N1) virus infection of rhesus monkey-kidney (LLC-MK2) cells and human type II alveolar epithelial (A549) cells where it was differentially expressed. Silencing of the RhebL1 gene led to increased NWS/33 virus infection in A549 cells and hyperphosphorylation of cytokeratin 8. These data suggests that RhebL1 appears to be a restrictive factor against NWS/33 virus replication in A549 cells.
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Why is it important?
There is currently a paucity of information on the role of RhebL1, specifically its involvement in viral infection. The article shows the involvement of RheBL1 in influenza A virus infection.
Perspectives
The results are worthy of further investigation to develop broad-range antiviral therapies.
Prof. Flora De Conto
Universita degli Studi di Parma
Read the Original
This page is a summary of: Host Cell-dependent Modulatory Role of Ras Homolog Enriched in Brain-Like-1 (RhebL1) Protein in Influenza A/NWS/33 Virus-infected Mammalian Cells, Frontiers in Bioscience-Landmark, March 2024, IMR Press,
DOI: 10.31083/j.fbl2903116.
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