What is it about?
A green approach for the synthesis of polyfunctionalized pyrrolo[2,3-d]pyrimidine derivatives was successfully achieved by a one-pot three-component reaction of arylglyoxals, 6-amino-1,3-dimethyluracil and barbituric acid derivatives in the presence of tetra-n-butylammonium bromide (TBAB) (5 mol%) as the catalyst in ethanol at 50 °C.
Featured Image
Why is it important?
This protocol has many advantages such as high yields (73-95%), green and simple procedure, short reaction times, easy work-up, mild reaction conditions and general applicability.
Perspectives
Our method provides a simple synthesis of polyfunctionalized pyrrolo[2,3-d]pyrimidine derivatives with different substituents, which may have pharmaceutical and biological applications.
Dr. Ramin Javahershenas
Urmia University
Read the Original
This page is a summary of: One-pot, three-component synthesis of pyrrolo[2,3-d]pyrimidine derivatives, Journal of the Mexican Chemical Society, May 2018, Sociedad Quimica de Mexico, A.C.,
DOI: 10.29356/jmcs.v62i1.340.
You can read the full text:
Resources
Contributors
The following have contributed to this page
