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An outbreak of Ralstonia mannitolilytica  bloodstream infections occurred in four hospitals in northeastern Italy, involving 20 haemodialysis patients with tunnelled central vascular catheter access. We identified as the outbreak source a batch of urokinase vials imported from India contaminated with R. mannitolilytica.  Whole genome sequences of the clinical and urokinase strains were highly related, and only urokinase-treated patients were reported with  R. mannitolilytica infections (attack rate = 34%; 95% confidence interval: 22.1–47.4). Discontinuation of the contaminated urokinase terminated the outbreak.

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This page is a summary of: A urokinase-associated outbreak of Ralstonia mannitolilytica bloodstream infections in haemodialysis patients in north-eastern Italy, January to April 2023, Eurosurveillance, July 2023, European Centre for Disease Control and Prevention (ECDC),
DOI: 10.2807/1560-7917.es.2023.28.28.2300328.
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