Natural Ingredients inhibit adverse health consequences caused by advanced glycation end products

What is it about?

Dietary advanced glycation end products (AGEs) may result in various adverse health consequences, such as inflammation, cancer, liver diseases, obesity, cardiovascular diseases, diabetes, proteostatis impairment and memory decline. Natural ingredients may be a promising strategy to inhibit AGEs generation and ameliorate health risks of AGEs. The mechanisms involved in inhibition of AGEs with use of natural ingredients include antioxidant activity, reactive carbonyl trapping, and suppressing pathways of RAGE (receptor of advanced glycation end product), MAPK (mitogen-activated protein kinases) and NF-κB (nuclear factor-kappa B).This mini review summarizes the present understanding of the adverse impact of AGEs on health and the inhibitory effect of natural ingredients on AGEs.

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Why is it important?

dietary AGEs may lead to the induction and progression of various health problems such as inflammation, cancer, liver diseases, obesity, cardiovascular diseases, diabetes, proteostatis impairment and memory decline. Natural ingredients may serve as an approach to reducing AGEs generation, and the involved inhibition mechanisms are antioxidant activity, reactive carbonyl trapping, and disruption of RAGE-MAPK signaling and NF-κB activation. Generally speaking, the natural ingredients are promising intervention tools to control content of AGEs. Meanwhile, we need to realize that there are many unexplored areas and ongoing challenges. Molecular mechanisms involved in health risks of dietary AGEs should be fully understood in details, and more in vivo animal and human studies should be conducted to confirm the inhibitory effects of natural ingredients on AGEs generation

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