ASSOCIATION BETWEEN SERUM RESISTIN LEVEL AND PERIODONTAL CONDITION CHANGE AMONG ELDERLY PEOPLE

What is it about?

Aim: This study aimed to compare periodontal condition in four years of Japanese elderly between high and low serum resistin levels. Materials and methods: One hundred and thirty-two dentate community-dwelling participants enrolled in this cohort study. At baseline, blood sample were drawn for serum resistin and other adipokines/cytokines measurements. The participants were then divided into 2 groups; low resistin (LR, resistin < 5.3 ng/mL) group (n = 84) and high resistin (HR, resistin ≥ 5.3 ng/mL) group (n = 48). At baseline and after four years, all participants were subjected to periodontal examination (assessment pocket depth; PD and bleeding on probing; BOP). Annual general/oral health questionnaires were also performed. Intergroup comparisons of periodontal parameters and categorical variables were accomplished by t-test and Chi-square test, respectively. Association between baseline serum resistin level and periodontal condition alteration after four years in each group were analyzed by a multiple linear regression analysis. Results: At baseline, HR group had more sites with PD ≥ 4 mm concomitant BOP than those of LR group (5.8±9.0 vs. 2.8±4.8 sites). High serum resistin concentration and number of tooth loss markedly associated with reduction of sites with PD ≥ 4 mm and PD ≥ 4 mm concomitant BOP. Conclusion: High serum resistin level might negatively be associated to periodontal disease progression. Keywords: adipokine, elderly, inflammation, periodontitis, resistin.

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