What is it about?
Etifoxine is a minor tranquillizer, usually well tolerated. A 77-y. old female suffered moderately intense secretory diarrhoea which started 3 w. after taking etifoxine 150 mg/d. Microscopic examination showed typical, diffuse lymphocytic colitis. Stools returned to normal within 3 w. after stopping the medication. Re-introduction led to relapse after 1 w. of more severe diarrhoea and colonic lesions. Diarrhoea vanished after 3w. and, 6 w. later rectal biopsy elicited a frank lessening of chorionic infiltration without changing of intra-epithelial lymphocytosis. A 3rd colonoscopy was not considered ethical.
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Why is it important?
Etifoxine has never been blamed yet for drug-induced colitis.Imputability seem almost certain, taking in account relapse and improvement of microscopic examination. Moreover, microscopic normalization delay is poorly known.
Perspectives
It's important to be aware of rare drug-induced to know to think of it.
Dr bernard maroy
Read the Original
This page is a summary of: Colite lymphocytaire probablement due à l'étifoxine : un cas avec rechute après réintroduction, Therapies, March 2009, Elsevier,
DOI: 10.2515/therapie:2009019.
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