What is it about?
In this research work, the effects of nonionic stabilizers on the physical stability of drug nanosuspensions were investigated. For this purpose five nonionic polymers (hydroxypropylmethyl cellulose (HPMC), Hydroxypropyl cellulose (HPC), polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP) and pluronic F68) and esomeprazole were selected as stabilizers and drug candidate, respectively.
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Why is it important?
Esomeprazole nanosuspensions were prepared using five polymeric nonionic stabilizers, and these nanosuspensions were investigated for their physical stability under different stress conditions. In this research work, the increase in particle size was observed in the nanosuspensions due to their physical instability (Ostwald ripening). Sometime, increase in the amount of stabilizer did not exhibit a significant effect on the ripening rate. However, in most cases, relatively lower rate of particle size increase was observed in this study with higher concentration of stabilizers. The changes in the crystalline state of esomeprazole in the nanosuspensions were confirmed by powder X-ray diffraction (PXRD) and Differential scanning calorimetry (DSC) analysis.
Perspectives
The issues of physical stability related to nanosuspensions are generally solved by using the different type of stabilizers. However, the screening process used for selecting the proper stabilizer arises a very critical, demanding and challenging issue. This is mainly due to lack of suitable technique used for selecting the proper stabilizers. Nowadays, generally hit and trial method is using for screening the stabilizers. Thus, this untouched field demands a needful work in future.
vijay agarwal
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This page is a summary of: Investigation of Effect of Non-Ionic Stabilizers on the Physical Stability of Drug Nanosuspension Prepared By Bottom Up Approach, International Journal of Pharmaceutical Sciences and Drug Research, August 2016, International Journal of Pharmaceutical Sciences and Drug Research,
DOI: 10.25004/ijpsdr.2016.080401.
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