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There is increasing appreciation of the individual differences among people with diabetes, with variable response to treatment and prognosis. This is particularly relevant for type 2 diabetes. In a brief report in this issue of Diabetes Care, a study from Michael Roden and colleagues has provided new insights regarding the clinical relevance of the clusters and the underlying pathophysiology. The study provides a good illustration of detailed characterisation, together with biomarkers analyses, can help uncover the complexity and heterogeneity of diabetes, and provide advances towards precision management of diabetes.

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This page is a summary of: Unravelling Diabetes Endotypes and Associated Pathophysiology for Precision Medicine in Diabetes: Ready for Prime Time?, Diabetes Care, November 2025, American Diabetes Association,
DOI: 10.2337/dci25-0067.
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