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People with severe insulin-resistant diabetes (SIRD) show higher levels of intrahepatic lipids and visceral adipose tissue compared to other diabetes endotypes, even after adjusting for BMI. This is linked to a higher cardiovascular risk, suggesting a need for targeted prevention and treatment strategies for SIRD.

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This page is a summary of: Role of Adipose Tissue Compartments for Cardiovascular Risk in Diabetes Endotypes, Diabetes Care, June 2025, American Diabetes Association,
DOI: 10.2337/dc24-2023.
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