Coeliac disease in newly diagnosed type 1 diebet

What is it about?

The European Society of Gastroenterology, Hepatology and nutrition updated its guidelines for diagnosis of coeliac disease in 2020 adopting a non-biopsy approach if coeliac disease serology (TGA-IgA) was elevated more than 10 times the upper normal limit and endomysial antibodies (EMA) were positive in a second serum sample. However, EMA is expensive and not readily available in many regions of the world, Which raised the question: Can we diagnose coeliac disease based on TGA-IgA alone?

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Why is it important?

Elevated TGA-IgA levels are common at diagnosis of T1D and do not consistently predict CD. Our data support repeating serology and pursuing biopsy in those with persistent elevation of TGA-IgA to avoid overdiagnosis of CD in children with newly diagnosed