Insulin Sensitivity and β-Cell Function During Early and Late Pregnancy in Women With and Without Gestational Diabetes Mellitus

What is it about?

We show that women who develop gestational diabetes, compared to those who do not, have worse insulin resistance and β-cell dysfunction early during pregnancy and a greater subsequent decline in insulin sensitivity and blunted increase in β-cell function. Increased fasting and one-hour OGTT plasma glucose early during pregnancy are markers of increased gestational diabetes risk.

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