What is it about?
Types 2 diabetes is a disease that was once almost exclusively among adults, but its prevalence has been increasing dramatically in children. We wanted to evaluate if the genetics that contribute to adult T2D played a role in glucose-insulin homeostasis in a population of youth from about 10-16 years old.
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Why is it important?
There have been very few genetic studies of youth-onset T2D. Understanding the genetics of this condition is particularly important because prevention is far preferable to disease management and treatment – and prevention earlier in life is more likely to be effective than later. T2D has a wealth of complications (neuropathy, vision degradation, cardiovascular disease, renal disease), and so prevention is really important. Our work also suggests that maintaining a healthy weight might be particularly important for children who have higher genetic predisposition for T2D.
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This page is a summary of: Genetic Risk Score for Type 2 Diabetes and Traits Related to Glucose-Insulin Homeostasis in Youth: The Exploring Perinatal Outcomes Among Children (EPOCH) Study, Diabetes Care, July 2021, American Diabetes Association, DOI: 10.2337/dc21-0464.
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