Heterogeneity of DKA Incidence and Age-Specific Clinical Characteristics in Children Diagnosed With Type 1 Diabetes in the TEDDY Study

What is it about?

The Environmental Determinants of Diabetes in the Young (TEDDY) study follows children from birth with high genetic risk for the development of type 1 diabetes. We sought to compare clinical and laboratory features based on age at diagnosis. Younger children had fewer autoantibodies with more symptoms at diagnosis. 6% (23/379) of TEDDY children experienced diabetic ketoacidosis (DKA) at onset with a greater rate in those who were young, those without a first degree relative, and those who had not been adherent with the TEDDY study protocol. A reduction in DKA rates remains an important benefit of monitoring programs such as TEDDY but regular follow up within the program is essential.

Featured Image