What is it about?

This work shed new light on risk of type 1 diabetes in children seroconverting to single autoantibody in the pre-symptomatic period. Their risk in general is much less, but especially lower if they have low-risk HLA class II genotypes. While its known that children with multiple autoantibodies progress to developing type 1 diabetes in 5 to 15 years, this work has shown that having multiple autoantibodies at seroconversion, the earliest timepoint in development of autoimmunity, can reliably predict development of type 1 diabetes in up to 15 years in future.

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Why is it important?

These findings have implications for prevention trial recruitment as well as clinical practice in counseling young children and families.

Perspectives

The T1DI cohort which is a harmonized dataset from 5 past large birth cohort studies (Finland, Germany, Sweden, and two US studies) is the largest (~24k subjects) cohort of its kind that has followed young children and adults for a period of 15 years or more or until their diagnosis. This study utilized the T1DI cohort for analyses of those starting followup by 2.5 yrs if not earlier.

Vibha Anand

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This page is a summary of: Islet Autoimmunity and HLA Markers of Presymptomatic and Clinical Type 1 Diabetes: Joint Analyses of Prospective Cohort Studies in Finland, Germany, Sweden, and the U.S., Diabetes Care, June 2021, American Diabetes Association,
DOI: 10.2337/dc20-1836.
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