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We show that circulating succinate, a metabolite previously described as a pathological inflammatory marker, has a meal-related response dependent on glucose sensing by the gastrointestinal tract. This response is blunted in patients with morbid obesity and type 2 diabetes and is recovered after weight loss.
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This page is a summary of: Impaired Succinate Response to a Mixed Meal in Obesity and Type 2 Diabetes Is Normalized After Metabolic Surgery, Diabetes Care, July 2020, American Diabetes Association,
DOI: 10.2337/dc20-0460.
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