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The insulin granule is more than just a hormone repository in pancreatic beta-cells or the site of proteolytic conversion of proinsulin into insulin. It also proves to be a major source of target antigens stimulating islet autoreactive T-cells. This commentary discusses a new report supporting and extending this notion and puts it into context..

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This page is a summary of: There Is Something About Insulin Granules, Diabetes, November 2020, American Diabetes Association,
DOI: 10.2337/dbi20-0039.
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