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The development of adipose tissue dysfunction is a key step in the pathophysiology of whole-body insulin resistance and metabolic disease. In three separate cohorts of humans with obesity we found that alterations in the non-classic insulin signaling pathway (TC10-TUG), which participates in the regulation of adipocyte glucose uptake, are associated with adipose dysfunction and insulin resistance.
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This page is a summary of: Altered Molecular Regulation of TUG Is a Central Feature of Insulin-Resistant Human Adipose Tissue, Diabetes, December 2025, American Diabetes Association,
DOI: 10.2337/db25-0488.
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