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We tested a long-acting version of LEAP2, a natural blocker of the hunger hormone ghrelin, and found it reduces body weight in obese mice by lowering food intake while maintaining energy use. When combined with semaglutide, it may further enhance weight loss and reduce weight regain.

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This page is a summary of: Sustained Weight Loss With Combined LEAP2 and Semaglutide Treatment in Mice, Diabetes, July 2025, American Diabetes Association,
DOI: 10.2337/db24-1056.
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