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We sought to elucidate the role of the intrarenal renin-angiotensin system (iRAS) in diabetic kidney disease (DKD) progression. Our study indicates that iRAS inactivation may be a potential approach for preventing DKD disease severity and its progression.

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This page is a summary of: Renal Tubule-Specific Angiotensinogen Deletion Attenuates SGLT2 Expression and Ameliorates Diabetic Kidney Disease in Murine Models of Type 1 Diabetes, Diabetes, January 2025, American Diabetes Association,
DOI: 10.2337/db24-0553.
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