Distinct Amino Acid Profile Characterizes Youth With or at Risk for Type 2 Diabetes

What is it about?

BCAA and AAA are associated with increased risk for type 2 diabetes in adults. This relationship is unclear in youth with studies showing conflicting results. We aimed to determine if an amino-acid profile could be identified to characterize youth at risk for type 2 diabetes. We show that a metabolic signature of low Gly, low Gln-to-Glu ratio and elevated BCAA, AAA and Lys as well as increased short chain AcylCN may constitute a biomarker profile to identify youth at risk for β-cell failure.

Featured Image