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It is commonly known that obesity is a major contributing factor to type 2 diabetes. We show that lactate accumulation in fat tissue under obese condition plays a key role in initiating inflammation which in turn results in insulin resistance, a signature feature of type 2 diabetes.

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This page is a summary of: Lactate Is a Key Mediator That Links Obesity to Insulin Resistance via Modulating Cytokine Production From Adipose Tissue, Diabetes, January 2022, American Diabetes Association,
DOI: 10.2337/db21-0535.
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