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We show that mTORC1 regulates insulin secretion through modulation of autophagy. Stimulation of mTORC1 by elevated leucine and glucose, which is common in obesity, may promote hyperinsulinemia by inhibiting autophagy.

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This page is a summary of: Nutrient Sensor mTORC1 Regulates Insulin Secretion by Modulating β-Cell Autophagy, Diabetes, December 2021, American Diabetes Association,
DOI: 10.2337/db21-0281.
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