What is it about?
Adiponectin is a well-known adipokine that exerts insulin sensitizing and anti-inflammatory functions. Whereas the insulin sensitizing role of adiponectin has been extensively investigated, much less is known on the mechanism by which adiponectin exerts its anti-inflammatory function in obesity. Here, we report that enhancing adiponectin signaling in the liver by hepatic-specific knockout of its negative regulator APPL2 has impacts on both hepatic insulin sensitivity and inflammation.
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Why is it important?
Our findings reveal: 1) the physiological role of APPL2 in hepatocytes, 2) MCP-1 as a novel target of adiponectin action in liver, 3) the hepatic APPL2-mTORC1-MCP-1 axis as a potential pathway for treating overnutrition-induced liver inflammation, and 4) a new avenue to review the link of metabolism and inflammation.
Perspectives
We demonstrate in vivo role of hepatic APPL2 in promoting diet-induced inflammation and insulin resistance. By identifying innate immune factors, such as MCP-1, as targets of adiponectin action in hepatocytes, we reveal a mechanism by which adiponectin and adiponectin signaling prevent diet-induced chronic inflammation in the liver.
Lily Dong
University of Texas Health San Antonio
Read the Original
This page is a summary of: Adiponectin Alleviates Diet-Induced Inflammation in the Liver by Suppressing MCP-1 Expression and Macrophage Infiltration, Diabetes, March 2021, American Diabetes Association,
DOI: 10.2337/db20-1073.
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