Cardiac Tissue Factor Regulates Inflammation, Hypertrophy, and Heart Failure in Mouse Model of Type 1 Diabetes

What is it about?

Diabetes patients have an increased risk of heart failure (HF). Diabetes is highly prevalent in HF with preserved ejection fraction (HFpEF), which is on the rise worldwide. We examined the role of Tissue factor (TF), a transmembrane receptor, in diabetes-induced cardiac inflammation, hypertrophy, and HF. We found TF causes increased inflammation and cardiac hypertrophy in diabetic mice compared to non-diabetic controls, while promoting survival of the cardiomyocytes against diabetes-induced apoptosis. Tissue factor also caused cardiac dysfunction, mainly diastolic dysfunction in diabetic mice versus controls and loss of TF protects against these abnormalities.

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