Diabetic Kidney Disease Alters the Transcriptome and Function of Human Adipose-Derived Mesenchymal Stromal Cells but Maintains Immunomodulatory and Paracrine Activities Important for Renal Repair

What is it about?

Cell-based therapy is a promising tool for the treatment of diabetic kidney disease. However, it is unclear whether stem cells taken from patients with diabetic kidney disease function differently compared to individuals of similar age without diabetes or kidney disease. We examined mesenchymal stem cell function and transcriptome of patients with diabetic kidney disease. Despite observed cell function and transcriptome differences compared to controls, cells from patients with diabetic kidney disease maintain many functions important for kidney repair. These findings support clinical trials testing patient-derived mesenchymal stem cell therapy in diabetic kidney disease.

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