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Identification of novel factors that regulate adipocyte metabolism could enable new therapeutic strategies to ameliorate insulin resistance. We here report that the valine degradation product, 3-hydroxyisobutyrate (3-HIB), not only serves as strong circulating marker for insulin resistance, but also directly affects the function of white and brown adipocytes.

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This page is a summary of: 3-Hydroxyisobutyrate, A Strong Marker of Insulin Resistance in Type 2 Diabetes and Obesity That Modulates White and Brown Adipocyte Metabolism, Diabetes, June 2020, American Diabetes Association,
DOI: 10.2337/db19-1174.
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