What is it about?
Diabetes is due to a lack of the hormone called insulin that can lower blood glucose. Here we present how new cells that produce insulin can be formed in mice. They are formed from dormant cells upon stimulation by signals circulating in the blood of these mice in situations where more insulin is required.
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Why is it important?
We propose a model of mice that display the formation of new cells producing insulin. Since diabetes originates from a lack of insulin, our results are the proof of concept that new insulin-producing cells can be formed upon the stimulation of signals present in the blood. Such signals represent exciting new therapeutic agents that could be used to treat diabetes.
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This page is a summary of: Adaptive β-Cell Neogenesis in the Adult Mouse in Response to Glucocorticoid-Induced Insulin Resistance, Diabetes, October 2018, American Diabetes Association, DOI: 10.2337/db17-1314.
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