Finerenone outcomes by insulin resistance

What is it about?

People with insulin resistance (meaning their body does not respond well to insulin) are more likely to be at risk of heart and kidney disease. Insulin resistance is often seen in people who are in the early stages of chronic kidney disease (CKD), and it happens more frequently as CKD gets worse. Estimated glucose disposal rate (an equation containing waist circumference, blood pressure status, and the amount of sugar in a person’s blood cells) is frequently used in medical practice to estimate insulin resistance in people with diabetes.

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Why is it important?

This analysis of two recent clinical trials shows that insulin resistance leads to a higher risk of heart (but not kidney) complications in people with diabetes and CKD. This analysis also shows that the drug finerenone, which has been shown to be beneficial for patients with diabetes and CKD, is effective regardless of insulin resistance.

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