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We show that the common gene variant KCNJ11-E23K increases diabetes risk by reducing insulin secretion at threshold glucose levels. Pro-diabetic effects were magnified on a high fat diet. Our results help explain why and when some people are genetically more at risk of developing diabetes.

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This page is a summary of: The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion, Diabetes, February 2021, American Diabetes Association,
DOI: 10.2337/db20-0691.
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