What is it about?

Disturbances in insulin secretion underlie the development of type 2 diabetes. In this manuscript, we demonstrate that the protein VPS41 is required for glucose homeostasis by influencing insulin storage and regulated secretion. Absence of VPS41 leads to diabetes in mice.

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Why is it important?

Mutations within the VPS41 gene are associated with type 2 diabetes in humans. Our study further indicates that VPS41 might be a factor contributing to the development of the disease.


This study is the product of a fantastic collaboration between four research labs across three different continents.

Cedric Asensio
University of Denver

Read the Original

This page is a summary of: Pancreatic β-Cell–Specific Deletion of VPS41 Causes Diabetes Due to Defects in Insulin Secretion, Diabetes, November 2020, American Diabetes Association,
DOI: 10.2337/db20-0454.
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