What is it about?

In the UK Biobank, individuals with lower levels of LDL-C are more likely to have type-2 diabetes, and 31 genetic loci are identified that may help explain this phenomenon.

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Why is it important?

It helps understand how and why lower levels of LDL-C, which decreases risk of cardiovascular disease, can increase risk for developing type-2 diabetes. This could be relevant for individuals taking cholesterol-lowering medication, for example.


We hope that this paper will help us better understand the ways in which cardiovascular disease and type-2 diabetes are connected.

Yann Klimentidis

Read the Original

This page is a summary of: Phenotypic and Genetic Characterization of Lower LDL Cholesterol and Increased Type 2 Diabetes Risk in the UK Biobank, Diabetes, June 2020, American Diabetes Association, DOI: 10.2337/db19-1134.
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