What is it about?
In this study we identify the important role of a protein, Pik3r1 (a.k.a. p85apha), in steroid hormone glucocorticoid exposure induced degradation of triglycerides to fatty acids in adipose tissue by affecting the signaling event in lipid droplet of adipose tissue. We also found that this mechanism is involved in chronic or excess glucocorticoid treatment induced dyslipidemia.
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Why is it important?
Glucocorticoids are stress hormones whose levels are higher in the population whose are in stressed conditions. Glucocorticoids are also frequently used for anti-inflammatory and immunomodulatory agents. Chronic and excess glucocorticoid exposure could cause dyslipidemia, which could lead to the development of cardiovascular diseases. This study provide a novel mechanism of how glucocorticoid affecting adipose function that potentially can cause dyslipidemia. Thus, targeting the pathway identified in this study could provide a novel approach to address this pathological effect.
Perspectives
This study not only provide a novel glucocorticoid regulated pathway on lipid homeostasis but also reveal a new function for the protein Pik3r1 in the regulation of protein kinase A signaling in lipid droplet of adipocytes.
Jen-Chywan Wang Wang
University of California Berkeley Department of Nutritional Sciences & Toxicology
Read the Original
This page is a summary of: Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis, Diabetes, March 2017, American Diabetes Association,
DOI: 10.2337/db16-0831.
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