Nonlifestyle Treatment of Prediabetes

What is it about?

The Endocrine Society has recommended using vitamin D supplementation in people with prediabetes because it may be beneficial in preventing or delaying the development of diabetes and unlikely to cause harm. In 9 randomized controlled trials, there was a 2.7% decrease in developing diabetes between people receiving vitamin D and placebo. In 12 randomized controlled trials, there was an 11.1 % decrease in developing diabetes in people taking weight loss drugs compared with those receiving a placebo. Weight loss reduces insulin resistance which allows the impaired insulin secretion of prediabetes to be more effective and at least delay the development of diabetes. Only 1.8% developed diabetes compared with 12.9% receiving a placebo, a 7-fold difference. Vitamin D has no effect on insulin secretion or insulin resistance.

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