What is it about?

Metformin is one of the most used drugs for the treatment of diabetes, and it has been used in humans for more than 60 years now. Its mechanism of action is not well understood, but it seems to decrease glucose production in the liver and glucose metabolism in the gut. Metformin considerably reduces A1C (by $1.12% as monotherapy and 0.95% when added to other drugs). Metformin's application in type 2 diabetes and other pathologies is explored, as well as this drug's strong point. The potential adverse effects and precautions required for its use are also explored. Finally, some practical indications for the use of this drug are detailed.

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Why is it important?

This article explores practical aspects concerning metformin, one of the most widely used and important antidiabetic drugs.

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This page is a summary of: Recommendations for Practical Use of Metformin, a Central Pharmacological Therapy in Type 2 Diabetes, Clinical Diabetes, November 2021, American Diabetes Association,
DOI: 10.2337/cd21-0043.
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