What is it about?

Hyperthermia mediated cispatin delivery system where cisplain is encapsulated by a heat-senstive liposome at hypertermal temperature 42 degree and it is released at the heated tumor.

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Why is it important?

Heat-sensitive liposome is prepared by the composition of DPPC: DSPC (=9:1) (phase-transition temperature, around 42 degree) so that the liposome can release an encapsulated agent at this narrow range of temperatures (41 to 45).

Perspectives

This delivery system is useful for targeted anti-cancer therapy.

Dr Katsumi Iga
Doshisha Joshi Daigaku

Read the Original

This page is a summary of: Treatment of Murine SCC VII Tumors with Localized Hyperthermia and Temperature-Sensitive Liposomes Containing Cisplatin, Radiation Research, May 1990, JSTOR,
DOI: 10.2307/3577601.
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