What is it about?
We aimed at assessing the interaction between visceral adipose tissue (VAT), insulin resistance (IR), circulating levels of monocyte chemoattractant protein-1 (MCP-1) and malondialdehyde (MDA) and the thyroid parameters in obese subjects.
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Why is it important?
Our study's novelty consists of the complex, integrative analyses of the associations between metabolic markers, systemic inflammation, OS and thyroid parameters, and their evaluation as possible risk factors for the changes in thyroid morpho-functioning, commonly observed in subjects with obesity.
Perspectives
Systemic inflammation increased with visceral adiposity, IR, and was significantly correlated with the frequency and the severity (TPOab levels) of HT, suggesting that, in obesity, MCP-1 could be part of the Nicoleta Răcătăianu et al. 146 etiopathogenesis of autoimmune thyroiditis. OS (MDA) increased significantly with systemic inflammation (MCP1) and it was an independent risk factor for the occurrence of hypothyroidism, sustaining that redox imbalance associated with obesity can produce cell damage and contribute to the pathophysiology of thyroid dysfunction. A significantly increased level of fT3 in insulin-resistant vs. non-insulin-resistant patients supports the value of fT3 as a marker for the severity of metabolic impairments in patients with obesity
PhD, MD racataianu nicoleta
UMF Iuliu Hatieganu Cluj-Napoca Romania
Read the Original
This page is a summary of: The crosstalk between insulin resistance, systemic inflammation, redox imbalance and the thyroid in subjects with obesity, Journal of Mind and Medical Sciences, April 2021, Valparaiso University,
DOI: 10.22543/7674.81.p139148.
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