Características clínicas e histológicas de las enfermedades parenquimatosas renales en una muestra de biopsias renales obtenidas entre el año 2002 y el 2017 en el departamento de Caldas, Colombia

What is it about?

Background: Renal syndromes are clinical and laboratory manifestations that indicate functional and morphological alterations. Renal biopsy is essential in the diagnosis of kidney parenchymal diseases and provides valuable information in incidence, distribution and possible control of the disease. Objective: To describe the clinical and histological characteristics of renal parenchymal diseases in a sample of renal biopsies. Methods: We included 269 patients older than 14 years who underwent renal biopsy by any method. They were classified by indication of biopsy and by type of primary or secondary kidney injury. Results: The average age was 57,04 (SD ± 17,17 years). The median creatinine was 1,51 mg / dL (RIC=1,22 - 2,01) and the GFR for CKD- EPI was 42,7 mil/minute (RIC=30,6 - 56,5). The most frequent renal biopsy indications were unexplained chronic kidney disease (46,8 %), non-nephrotic proteinuria (20,1 %), nephritic syndrome (8,2 %), acute kidney injury (7,1 %), glomerular hematuria with change in the pattern (7,1 %), nephrotic syndrome (6,7 %) and unexplained low glomerular filtration for age (4,1 %). The most frequent finding were IgA nephropathy (20,9 %), hypertensive nephropathy (19 %), focal and segmental glomerulosclerosis (11,6 %), tubulointerstitial nephritis (9,7 %), diabetic glomerulopathy (8,6 %), membranoproliferative glomerulonephritis (3,7 %), extracapillary proliferative glomerulonephritis (3,4 %). Conclusions: IgA nephropathy and focal segmental glomerulosclerosis are the main primary glomerulopathies. Hypertensive nephropathy and tubulointerstitial nephritis are the main secondary etiologies.

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