What is it about?
Opioids are widely used as effective analgesics, but opioid sensitivity is well known to vary widely among individuals. This paper explored the genetic factors that contribute to individual differences in intraoperative opioid sensitivity by performing a genome-wide association study in subjects who underwent laparoscopic-assisted colectomy. As a result, several genetic variations were found to be associated with intraoperative opioid requirements.
Featured Image
Why is it important?
The findings provide valuable information for personalized pain treatment during laparoscopic-assisted colectomy.
Perspectives
Identifying genotypes of the candidate genetic polymorphisms may provide valuable information to better modulate individual analgesic dosages that are required to achieve satisfactory pain control in clinical practice. I hope our findings contribute to a better understanding of individual differences in opioid sensitivity and may prompt future studies of the personalized treatment of pain.
Daisuke Nishizawa
Tokyo Metropolitan Institute of Medical Science
Read the Original
This page is a summary of: Genome-wide scan identifies candidate loci related to remifentanil requirements during laparoscopic-assisted colectomy, Pharmacogenomics, January 2018, Future Medicine,
DOI: 10.2217/pgs-2017-0109.
You can read the full text:
Resources
Contributors
The following have contributed to this page
