What is it about?
Novel plastic nanoparticles containing small amounts of a pigment were prepared and tested for their ability to kill brain and colorectal cancer cells upon illumination with visible light. We showed that even at low light doses, these nanoparticles generate toxic species derived from oxygen which damage cellular components leading to programmed cell death.
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Why is it important?
The novel plastic nanoparticles proved to be effective for the light based treatment of cancerous tumor cells and did not show intrinsic toxicity in the absence of light. Our results showed that tumor cells efficiently incorporated the particles and, regardless of the cellular location, they were very effective inducing a non inflammatory cell death. The low light and particle doses needed to achieve the killing of cancerous cells bode well for the development of successful clinical treatments based on these material.
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This page is a summary of: Metallated porphyrin-doped conjugated polymer nanoparticles for efficient photodynamic therapy of brain and colorectal tumor cells, Nanomedicine, March 2018, Future Medicine,
DOI: 10.2217/nnm-2017-0292.
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