What is it about?
We used resveratrol-loaded nanoparticles (Res NPs) as a novel method for improving the pharmacokinetic properties of Res and analyzed the effect of Res NPs in chronic kidney disease (CKD). Res NPs through NLRP3 inflammasome attenuation and autophagy induction may be as a strategy to prevent CKD.
Featured Image
Why is it important?
Res NPs had low toxicity and induced autophagy. Res NPs inhibited the NLRP3 inflammasome and IL-1β secretion. Higher NLRP3 expression levels were observed in peripheral blood monocytic cells of CKD patients than healthy individuals. Treatment with kidney injury molecule-1-Res NPs significantly reduced creatinine and protected against tubulointerstitial injury in a murine model of CKD.
Perspectives
Res NPs through NLRP3 inflammasome attenuation and autophagy induction may be as a strategy to prevent CKD.
Hui-Wen Chiu
Taipei Medical University
Read the Original
This page is a summary of: Resveratrol-loaded nanoparticles conjugated with kidney injury molecule-1 as a drug delivery system for potential use in chronic kidney disease, Nanomedicine, November 2017, Future Medicine,
DOI: 10.2217/nnm-2017-0256.
You can read the full text:
Contributors
The following have contributed to this page
