What is it about?
This paper provides a narrative overview and review of the potential role for ACE Inhibitors, a common used anti-hypertensive, in the treatment of Alzheimer's type dementia. The paper describes the possible mechanisms for this effect and explains the evidence both for and against this.
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Why is it important?
As no disease modifying medication are yet available for treating Alzheimer's disease looking for medications that are commonly used and may have additional benefit beyond their traditional role is important. It emphasizes the important of control of hypertension in Alzheimer's disease and other dementias.
Perspectives
Several studies show the importance of managing hypertension in dementia. The potential beneficial effects seem to go beyond the BP lowering factor and point to other mechanisms that could if confirmed and clearly illustrated have a meaningful impact on those with the condition. Marginal gains, while small may be additive and have beneficial effects over years or decades. Further research is needed and is ongoing.
Rónán O'Caoimh
National University of Ireland - Galway
Read the Original
This page is a summary of: Use of angiotensin-converting enzyme inhibitors for Alzheimer’s disease: an update, Neurodegenerative Disease Management, December 2013, Future Medicine,
DOI: 10.2217/nmt.13.61.
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