What is it about?
In this clinical study we have found Human Cytomegalo Virus (HCMV) UL97 protein (pUL97) amino acid substitutions in drug-naive congenitally infected neonates corresponding to Ganciclovir (GCV) resistance.
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Why is it important?
In the absence of drug pressure, existance of GCV resistance-conferring variations may suggest for congenitally transmission of GCV-resistance HCMV variants to newborns.
Perspectives
If a mother recieving GCV transfer the drug resistance viral variants to neonats, I can imagine َappearance of pUL97 drug resistance confering mutants. However, if a mom was not geting GCV, pUL97 mutants may only appear under influence of host immunity.
Mr. Alireza Mohebbi
Golestan University of Medical Sciences and Health Services
Read the Original
This page is a summary of: Human cytomegalovirus pUL97 drug-resistance mutations in congenitally neonates and HIV-infected, no-drug-treated patients, Future Virology, January 2017, Future Medicine,
DOI: 10.2217/fvl-2016-0089.
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