What is it about?
SHBG level was lower in women with GDM than in women without GDM (93.9 ± 34.4 nmol/l vs 128.1 ± 60.3 nmol/l; p = 0.001). Among the four quartiles (Q1–Q4) according to SHBG levels, GDM incidences were 17.5, 27.8, 5.1 and 2.6%, respectively. No differences were found between Q1 and Q2, and Q3 and Q4. The risk of developing GDM among women in Q1 + Q2 compared with Q3 + Q4 was 5.7.
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Why is it important?
Most GDM may be prevented by screening risk pregnant of high level SHBG.
Perspectives
We can measure SHBG to find high risk person and make intervention.
Wangen Li
Guangzhou Medical University
Read the Original
This page is a summary of: Sex hormone-binding globulin levels during the first trimester may predict gestational diabetes mellitus development, Biomarkers in Medicine, February 2018, Future Medicine,
DOI: 10.2217/bmm-2016-0030.
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