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Gold nanoparticles (GNPs) have currently become one of the most ideal nanomaterials for biomedical applications including drug delivery and imaging. However, recent reports about an acute phase increase in proinflammatory cytokines by GNPs reflect a negative impact on their medical applications. In this investigation, we report that a priming dose of GNPs significantly inhibits the induction of acute phase immune response in GNP-treated mice suggesting the importance of the priming dose in nanomedicine.

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This page is a summary of: A priming dose protects against gold nanoparticles-induced proinflammatory cytokines mRNA expression in mice, Nanomedicine, December 2017, Future Medicine,
DOI: 10.2217/nnm-2017-0332.
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