What is it about?

In this commentary, published in Future Cardiology, I present the current evidence regarding the counterregulatory effects of PDE5 inhibitors on SARS-CoV-2 replication and COVID-19-associated thromboembolism. Given the recent findings regarding the pathogenesis of SARS-CoV-2, and the pathways involved in COVID-19, resulting in pulmonary fibrosis and thromboembolism; it appears that PDE5 inhibitors could be good candidates in the clinical management of COVID-19 patients, especially those with a history of underlying cardiac and metabolic diseases.

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Why is it important?

With their dual inhibitory effects on SARS-CoV-2 3CL pro and the NO/cGMP/PDE5 pathway, PDE5 inhibitors suggestively act in more than one way against COVID-19, leading to the inhibition of viral replication and downregulation of pro-inflammatory pathways concerned with the induction of iNOS and instigation of thromboembolism.

Perspectives

I am thrilled to have published this commentary in Future Cardiology.

Milad Shirvaliloo
Tabriz University of Medical Sciences

Read the Original

This page is a summary of: Targeting the SARS-CoV-2 3CLpro and NO/cGMP/PDE5 pathway in COVID-19: a commentary on PDE5 inhibitors, Future Cardiology, February 2021, Future Medicine, DOI: 10.2217/fca-2020-0201.
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