What is it about?
Varicose vein disease is one of the most widespread disorders affecting human health worldwide. There is still a lack of knowledge regarding the mechanism that causes varicose vein formation. A few attempts have been made so far to apply OMICs technologies to elucidate mechanisms of this disease but none of them utilized methylome or even combined transcriptome and methylome approaches. Herein we made such an attempt and performed a thorough system biological analysis of well-controlled human samples using joint transcriptome and methylome analysis along with molecular biology and immunochemistry, as well as advanced bioinformatics analysis that allowed us to look at this problem from a different angle. By identifying differentially expressed and methylated genes and analyzing their promoter regions, using systems biological integrative approach, we found several important players in varicose vein pathogenesis. Profoundly, the study points to an important function for microfibril associated protein, MFAP5, as a potential key regulator of vascular remodeling of the veins.
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Why is it important?
A coherent model proposed incorporates the relevant signaling networks and will hopefully aid further studies on varicose vein pathogenesis.
Perspectives
This research work advances our understanding the molecular basis of the disease since it addresses the new insights regarding the mechanism which could be targeted to improve conditions causing varicose vein disease and could be relevant to researchers or developers in the field.
Mariya Smetanina
Institute of Chemical Biology and Fundamental Medicine (ICBFM) SB RAS
Read the Original
This page is a summary of: DNA methylation and gene expression profiling reveal MFAP5 as a regulatory driver of extracellular matrix remodeling in varicose vein disease, Epigenomics, August 2018, Future Medicine,
DOI: 10.2217/epi-2018-0001.
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